Pyruvate

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Pyruvate is a remarkable supplement that will help speed up your metabolism, boost your energy levels throughout the day and increase your endurance. These qualities make Pyruvate an excellent supplement for athletes. Pyruvate has also been proven to lower harmful cholesterol and to act as a powerful antioxidant. Laboratory tested to ensure the highest quality, potency and purity. Pharmaceutical grade.

What Is Pyruvate?

Pyruvate is a stabilized form of pyruvic acid and naturally occurs in the body. Pyruvate is the foundation of the Krebs, or Citric Acid, Cycle. This Cycle, further explained below, is the process through which the body converts Glycogen to Energy. Or, more simply, it is how the body burns sugar and starch. Thus, Pyruvate plays a crucial role in this conversion of food to energy.

For What Is Pyruvate Used?

Supplementation of Pyruvate increases cellular respiration, or the amount of energy the mitochondria (the cells' metabolic furnace) use. The more energy used, the less the body stores. In addition, Pyruvate has been known to lower cholesterol levels, increase endurance and benefit weight management.
 

Are There Any Side Effects With Pyruvate?

Pyruvate is 100% safe; it naturally occurs in the body as an end-product of the metabolism of sugar or starch. Supplementation with Pyruvate has been found to increase the metabolism, accelerating the burning of sugar and starch. The only side-effects observed from mega-doses of Pyruvate have been gastric distress (gas; a natural byproduct of digestion)--and this is from doses 10 times the recommended dosage.
 

The Krebs Cycle Explained
The following diagram shows the role of Pyruvate in the Krebs Cycle.
  1. There are ten steps to the Krebs Cycle. It takes 2 turns of the Krebs Cycle to metabolize each glycogen molecule*.
  2. The unstable bond of acetyl CoA breaks, and the two-carbon acetyl group bonds to the four-carbon oxaloacetic acid to form six-carbon citric acid.

  3. Two major events occur during this step: Isocitric acid loses carbon dioxide leaving a five-carbon molecule and the five-carbon compound is oxidized, reducing NAD+.
  4. A multienzyme complex catalyzes: the removal of carbon dioxide, the oxidation of the remaining four-carbon compound, reduction of NAD+, and the attachment of CoA with a high energy bond to form succinyl CoA.
  5. Substrate level phosphorylation occurs in a series of enzyme catalyzed reactions: the high energy bond in succinyl-CoA breaks, and some energy is conserved as CoA is displaced by a phosphate group. The phosphate group is transferred to GDP to form GTP and succinic acid. GTP donates a phosphate group to ADP to form ATP.
  6. Succinic acid is oxidized to fumaric acid and FAD is reduced: Two hydrogens are transferred to FAD to form FADH2 (FADH2 stores less energy than NADH.) The dehydrogenase that catalyzes this reaction is bound to the inner mitochondrial membrane.
  7. Water is added to fumaric acid which rearranges its chemical bonds to form malic acid.
  8. Malic acid is oxidized and NAD is reduced.
  9. A molecule of NADH is produced.
  10. Oxaloacetic acid is regenerated to begin the cycle again.
*Note that for every turn of the Krebs Cycle:
  • Two carbons enter in the acetyl fragment of Acetyl CoA.
  • Two different carbons leave as carbon dioxide.
  • Coenzymes are reduced; three NADH and one FADH2 are produced.
  • One ATP molecule is produced by substrate level phosphorylation.
  • Oxaloacetic acid is regenerated.
  • For every glucose molecule split during glycolysis, two acetyl fragments are produced. Thus, it takes two turns of the cycle to complete the oxidation of glucose.
  • Reduced coenzymes produced by the Krebs Cycle (6 NADH and 2 FADH2 per glucose) carry high energy electrons to the electron transport chain where ATP is produced by chemiosmosis. Most of the ATP output of respiration results from this oxidative phosphorylation.
Summary: To put all of this chemistry (which is admittedly difficult to follow) into laypersons' terms, the faster the Krebs Cycle turns, the more energy (ATP) a person has, and the more calories they burn. And, Pyruvate makes the Krebs Cycle run faster.

The statements herein have not been evaluated by the FDA, and are intended for educational purposes only. These products are not intended to treat, diagnose, cure , mitigate or prevent any disease. If you have a serious medical condition, consult with your doctor before using.

 
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