is a remarkable supplement that will help speed
up your metabolism, boost your energy levels throughout
the day and increase your endurance. These qualities
make Pyruvate an excellent supplement for athletes.
Pyruvate has also been proven to lower harmful
cholesterol and to act as a powerful antioxidant.
Laboratory tested to ensure the highest quality,
potency and purity. Pharmaceutical grade.
is a stabilized form of pyruvic acid and naturally occurs
in the body. Pyruvate is the foundation of the Krebs,
or Citric Acid, Cycle. This Cycle, further explained below,
is the process through which the body converts Glycogen
to Energy. Or, more simply, it is how the body burns sugar
and starch. Thus, Pyruvate plays a crucial role in this
conversion of food to energy.
What Is Pyruvate Used?
of Pyruvate increases cellular respiration, or the amount
of energy the mitochondria (the cells' metabolic furnace)
use. The more energy used, the less the body stores. In
addition, Pyruvate has been known to lower cholesterol
levels, increase endurance and benefit weight management.
There Any Side Effects With Pyruvate?
is 100% safe; it naturally occurs in the body as an end-product
of the metabolism of sugar or starch. Supplementation
with Pyruvate has been found to increase the metabolism,
accelerating the burning of sugar and starch. The only
side-effects observed from mega-doses of Pyruvate have
been gastric distress (gas; a natural byproduct of digestion)--and
this is from doses 10 times the recommended dosage.
Krebs Cycle Explained
following diagram shows the role of Pyruvate in the Krebs
that for every turn of the Krebs Cycle:
are ten steps to the Krebs Cycle. It takes 2 turns
of the Krebs Cycle to metabolize each glycogen molecule*.
unstable bond of acetyl CoA breaks, and the two-carbon
acetyl group bonds to the four-carbon oxaloacetic
acid to form six-carbon citric acid.
major events occur during this step: Isocitric acid
loses carbon dioxide leaving a five-carbon molecule
and the five-carbon compound is oxidized, reducing
multienzyme complex catalyzes: the removal of carbon
dioxide, the oxidation of the remaining four-carbon
compound, reduction of NAD+, and the attachment of
CoA with a high energy bond to form succinyl CoA.
level phosphorylation occurs in a series of enzyme
catalyzed reactions: the high energy bond in succinyl-CoA
breaks, and some energy is conserved as CoA is displaced
by a phosphate group. The phosphate group is transferred
to GDP to form GTP and succinic acid. GTP donates
a phosphate group to ADP to form ATP.
acid is oxidized to fumaric acid and FAD is reduced:
Two hydrogens are transferred to FAD to form FADH2
(FADH2 stores less energy than NADH.) The dehydrogenase
that catalyzes this reaction is bound to the inner
is added to fumaric acid which rearranges its chemical
bonds to form malic acid.
acid is oxidized and NAD is reduced.
molecule of NADH is produced.
acid is regenerated to begin the cycle again.
To put all of this chemistry (which is admittedly difficult
to follow) into laypersons' terms, the faster the Krebs
Cycle turns, the more energy (ATP) a person has, and the
more calories they burn. And, Pyruvate makes the Krebs
Cycle run faster.
carbons enter in the acetyl fragment of Acetyl CoA.
different carbons leave as carbon dioxide.
are reduced; three NADH and one FADH2 are produced.
One ATP molecule is produced by substrate level phosphorylation.
acid is regenerated.
every glucose molecule split during glycolysis, two
acetyl fragments are produced. Thus, it takes two
turns of the cycle to complete the oxidation of glucose.
coenzymes produced by the Krebs Cycle (6 NADH and
2 FADH2 per glucose) carry high energy electrons to
the electron transport chain where ATP is produced
by chemiosmosis. Most of the ATP output of respiration
results from this oxidative phosphorylation.
statements herein have not been evaluated by the
FDA, and are intended for educational purposes only.
These products are not intended to treat, diagnose,
cure , mitigate or prevent any disease. If you have
a serious medical condition, consult with your doctor